Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14683431 | 0.81 | NOTUM (0.47) | LMNASLC6A4NOTUMKMT2ATSHR | |
| SCHEMBL3374081 | 0.81 | NOTUM (0.47) | LMNASLC6A4NOTUMKMT2ATSHR | |
| SCHEMBL30641461 | 0.74 | SLC6A2 (0.50) | LMNASLC6A4NOTUMKMT2ASLC6A2 | |
| SCHEMBL11412911 | 0.74 | KMT2A (0.49) | LMNASLC6A4NOTUMKMT2ATSHR | |
| SCHEMBL2976520 | 0.73 | SLC6A4 (0.46) | SLC6A4NOTUMSLC6A2CDK4CCND1 | |
| SCHEMBL8573980 | 0.72 | SLC6A4 (0.53) | SLC6A4NOTUMSLC6A2CDK4CCND1 | |
| SCHEMBL2404377 | 0.72 | LMNA (0.41) | LMNASLC6A4NOTUMKMT2ATSHR | |
| SCHEMBL30611209 | 0.72 | SLC6A4 (0.44) | LMNASLC6A4KMT2ATSHRRAB9A | |
| SCHEMBL10203775 | 0.71 | NOTUM (0.53) | SLC6A4NOTUMKMT2ATSHRRAB9A | |
| SCHEMBL526316 | 0.71 | NOTUM (0.49) | SLC6A4NOTUMKMT2ATSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383742-B1 | SYNTHESIS AND METHODS OF USE OF TETRAHYDROINDOLONE ANALOGUES AND DERIVATIVES | SPECTRUM PHARMACEUTICALS INC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-5646300-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5591866-A | NEUROPROTECTIVE AGENTS | HOECHST MARION ROUSSEL INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5565579-A | NEUROPROTECTIVE AGENT | HOECHST MARION ROUSSEL INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0563916-B1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0563916-A1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | disclosed |