Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28710586 | 1.00 | KCNT1 (0.49) | KCNT1RAB9ATSHRNPC1SMN1; SMN2 | |
| SCHEMBL28706194 | 1.00 | KCNT1 (0.49) | KCNT1RAB9ATSHRNPC1SMN1; SMN2 | |
| SCHEMBL28710978 | 0.88 | MLLT1 (0.44) | TSHRMAPK1L3MBTL1 | |
| SCHEMBL28710950 | 0.87 | NPC1 (0.46) | RAB9ATSHRNPC1SMN1; SMN2MAPT | |
| SCHEMBL28713210 | 0.86 | S1PR3 (0.52) | RAB9ANPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL28713211 | 0.86 | S1PR3 (0.52) | RAB9ANPC1SMN1; SMN2HSD17B10TP53 | |
| SCHEMBL28710588 | 0.85 | S1PR1 (0.47) | KCNT1TSHRSMN1; SMN2TP53MAPK1 | |
| SCHEMBL28713701 | 0.84 | CA2 (0.55) | TSHRMAPK1L3MBTL1 | |
| SCHEMBL28935985 | 0.84 | CA9 (0.44) | KCNT1TSHRMAPK1L3MBTL1 | |
| SCHEMBL28701588 | 0.81 | KCNT1 (0.52) | KCNT1RAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269340-A | KCNT1 inhibitors and methods of use | 普拉克西斯精密药物股份有限公司 | 2022-04-01 | — | — | CN | disclosed |