Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 7/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28713701 | 0.91 | CA2 (0.55) | CA9CA2CA12CA1DPP4 | |
| SCHEMBL28710978 | 0.84 | MLLT1 (0.44) | DPP4DPP7FFAR1TSHRMAPK1 | |
| SCHEMBL28706194 | 0.84 | KCNT1 (0.49) | TSHRMAPK1L3MBTL1KCNT1 | |
| SCHEMBL28710586 | 0.84 | KCNT1 (0.49) | TSHRMAPK1L3MBTL1KCNT1 | |
| SCHEMBL28706195 | 0.84 | KCNT1 (0.49) | TSHRMAPK1L3MBTL1KCNT1 | |
| SCHEMBL28710950 | 0.83 | NPC1 (0.46) | DPP4DPP7FFAR1TSHRMAPK1 | |
| SCHEMBL22637707 | 0.82 | CA9 (0.50) | CA9CA2CA12CA1DPP4 | |
| SCHEMBL22649534 | 0.82 | CA9 (0.49) | CA9CA2CA12CA1DPP4 | |
| SCHEMBL28713211 | 0.82 | S1PR3 (0.52) | CA9CA2CA12CA1FFAR1 | |
| SCHEMBL28713210 | 0.82 | S1PR3 (0.52) | CA9CA2CA12CA1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269340-A | KCNT1 inhibitors and methods of use | 普拉克西斯精密药物股份有限公司 | 2022-04-01 | — | — | CN | disclosed |