SCHEMBL28707337

SCHEMBL28707337

FC(Cl)(Cl)c1cccc(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
MAPT P10636 2/20 0.43
MEN1 O00255 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP19A1 P11511 2/20 0.43
KIF11 P52732 3/20 0.42
TSHR P16473 2/20 0.41
MAPK1 P28482 2/20 0.37
PNMT P11086 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
OPRL1 P41146 1/20 0.36
CCR6 P51684 1/20 0.36
KCNH2 Q12809 1/20 0.36
HSD11B1 P28845 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11234202 0.85 PGK1 (0.44) ALDH1A1CYP1A2KIF11TSHRMAPK1
SCHEMBL592796 0.83 ALDH1A1 (0.58) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL29635769 0.83 ALDH1A1 (0.58) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL1504946 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL28270887 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL12811806 0.81 ALDH1A1 (0.43) ALDH1A1MAPTMEN1CYP1A2CYP3A4
Hydrogen Sulfide SCHEMBL28290770 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL1504949 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL10607069 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4
Water SCHEMBL28200366 0.81 ALDH1A1 (0.56) ALDH1A1MAPTMEN1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114105772-A Synthetic method of 2-chloro-4-fluoro-5-nitrobenzoic acid 阜新睿光氟化学有限公司 2022-03-01 CN disclosed