Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29951344 | 0.93 | GAA (0.59) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL7419408 | 0.84 | GAA (0.74) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL11317879 | 0.82 | GAA (0.72) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL8900419 | 0.82 | GAA (0.72) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL1742880 | 0.79 | GAA (0.68) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL13561972 | 0.79 | GAA (0.68) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL3454169 | 0.79 | KDM4E (0.59) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL29957897 | 0.79 | KDM4E (0.59) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL5109796 | 0.78 | GAA (0.66) | GAAHTTHPGDALDH1A1KDM4E | |
| SCHEMBL1934771 | 0.78 | ALDH1A1 (0.49) | GAAHTTHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299420-B | Pentacyclic compounds as selective estrogen receptor down-regulators and uses thereof | 南京圣和药业股份有限公司 | 2021-10-15 | — | — | CN | disclosed |