Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CD38 | P28907 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29467955 | 1.00 | GAA (0.52) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL6087010 | 0.84 | MEN1 (0.50) | KDM4EASPHRIOX2KDM8MEN1 | |
| SCHEMBL12725538 | 0.81 | HIF1A (0.53) | KDM4EASPHRIOX2KDM8MEN1 | |
| SCHEMBL28714008 | 0.81 | CA12 (0.49) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL29467971 | 0.81 | CA12 (0.49) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL13245806 | 0.80 | MAP2K4 (0.52) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL27711447 | 0.80 | GAA (0.50) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL27088526 | 0.79 | VNN1 (0.50) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL31726503 | 0.79 | HDAC1 (0.47) | GAAKDM4EASPHRIOX2KDM8 | |
| SCHEMBL9683331 | 0.78 | MAP2K4 (0.52) | GAAMAP2K4MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114206870-A | Tricyclic AKR1C3 dependent KARS inhibitors | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |