Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.72 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 8/20 | 0.45 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ASPH | Q12797 | 2/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30159768 | 1.00 | SIRT6 (0.72) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| SCHEMBL6078516 | 0.98 | SIRT6 (0.69) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| Hydrochloric Acid SCHEMBL30263277 | 0.98 | SIRT6 (0.69) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| Hydrochloric Acid SCHEMBL9310461 | 0.98 | SIRT6 (0.69) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| SCHEMBL28182374 | 0.90 | SIRT6 (0.60) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| SCHEMBL70035 | 0.84 | KDM4E (0.59) | SIRT6NAPRTKDM4EHCAR2P4HTM | |
| SCHEMBL31041116 | 0.84 | SIRT6 (1.00) | SIRT6NAPRTP4HTMP4HA1MIF | |
| SCHEMBL1432968 | 0.84 | SIRT6 (1.00) | SIRT6NAPRTP4HTMP4HA1MIF | |
| SCHEMBL30263065 | 0.83 | SIRT6 (0.68) | SIRT6NAPRTP4HTMP4HA1MIF | |
| SCHEMBL27741418 | 0.83 | SIRT6 (0.68) | SIRT6NAPRTP4HTMP4HA1MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462646-A | Substituted tetrahydro-beta-carboline derivative, synthesis method and application thereof | 江苏科技大学 | 2025-02-18 | — | — | CN | claimed |
| CN-113912534-B | Biphenyl heterocyclic compound, synthesis method and application thereof | 江苏科技大学 | 2023-07-25 | — | — | CN | claimed |
| US-11697636-B2 | Substituted benzamides | HOFFMANN-LA ROCHE INC. (US) | 2023-07-11 | — | — | US | claimed |
| WO-2023083161-A1 | BIPHENYL HETEROCYCLIC COMPOUND, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF | 江苏科技大学 | 2023-05-19 | — | — | WO | claimed |
| CN-113980025-B | Nicotine and indole hybrid compound, and synthesis method and application thereof | 江苏科技大学 | 2023-02-24 | — | — | CN | claimed |
| CN-113880847-B | Cyclotryptamine alkaloid, and synthesis method and application thereof | 江苏科技大学 | 2023-02-03 | — | — | CN | claimed |
| CN-113912534-A | Biphenyl heterocyclic compound, and synthesis method and application thereof | 江苏科技大学 | 2022-01-11 | — | — | CN | claimed |
| CN-113880847-A | Cyclotryptamine alkaloid, and synthesis method and application thereof | 江苏科技大学 | 2022-01-04 | — | — | CN | claimed |
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | HOFFMANN LA ROCHE (US) | 2021-03-04 | — | — | US | claimed |
| CN-107840828-B | Synthesis method of 2-chloro-5-trifluoromethylpyrazine | 金凯(辽宁)化工有限公司 | 2020-11-03 | — | — | CN | claimed |
| EP-2475658-A1 | 2 -AMINODIHYDRO [1, 3]THIAZINES AS BACE 2 INHIBITORS FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | claimed |
| EP-2456763-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2012-05-30 | — | — | EP | claimed |
| CN-102482268-A | 2-Aminodihydro [1,3] thiazines as BACE2 inhibitors for the treatment of diabetes | HOFFMANN LA ROCHE | 2012-05-30 | — | — | CN | claimed |
| CN-102471293-A | Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders | NOVARTIS AG | 2012-05-23 | — | — | CN | claimed |
| CN-102421760-A | Dihydropyrimidinones useful as BACE2 inhibitors | HOFFMANN LA ROCHE | 2012-04-18 | — | — | CN | claimed |
| WO-2012006953-A1 | OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2012-01-19 | — | — | WO | claimed |
| US-20110065695-A1 | USE OF AMINODIHYDROTHIAZINES FOR THE TREATMENT OR PREVENTION OF DIABETES | HOFFMANN-LA ROCHE, INC. | 2011-03-17 | — | — | US | claimed |
| WO-2010128058-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | claimed |
| US-20100286158-A1 | DIHYDROPYRIMIDINONES | HOFFMANN-LA ROCHE, INC. | 2010-11-11 | — | — | US | claimed |
| WO-2008050200-A1 | OXADIAZOLE COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-05-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061760-A1 | SUBSTITUTED BENZAMIDES | TAAR1, TAAR5, NPY1R | SIRT6 3673/4885NAPRT 904/4885KDM4E 1864/4885 |
| US-20110065695-A1 | USE OF AMINODIHYDROTHIAZINES FOR THE TREATMENT OR PREVENTION OF DIABETES | SLC5A2, SLC5A1, GLP1R | SIRT6 796/4885NAPRT 2801/4885KDM4E 1845/4885 |
| US-11697636-B2 | Substituted benzamides | TAAR1, TAAR5, NPY1R | SIRT6 3673/4885NAPRT 904/4885KDM4E 1864/4885 |
| US-20100286158-A1 | DIHYDROPYRIMIDINONES | BACE2, BACE1, PSEN2 | SIRT6 910/4885NAPRT 1927/4885KDM4E 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.