Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28721352 | 0.91 | HDAC1 (0.60) | JAK2HDAC6HDAC1CDK4CDK2 | |
| SCHEMBL28714701 | 0.86 | CDK4 (0.62) | JAK2HDAC6HDAC1CDK4CDK2 | |
| SCHEMBL28714706 | 0.85 | HDAC6 (0.63) | JAK2HDAC6HDAC1CDK4ACVR1 | |
| SCHEMBL28714813 | 0.85 | HDAC6 (0.62) | JAK2HDAC6HDAC1CDK4ACVR1 | |
| SCHEMBL28714708 | 0.83 | HDAC6 (0.62) | JAK2HDAC6HDAC1CDK4CDK2 | |
| SCHEMBL28676599 | 0.83 | CDK2 (0.57) | JAK2HDAC6HDAC1CDK4ACVR1 | |
| SCHEMBL28717945 | 0.77 | HDAC6 (0.75) | JAK2HDAC6HDAC1CDK4CDK2 | |
| SCHEMBL28680649 | 0.75 | SYK (0.48) | CDK2 | |
| SCHEMBL29372471 | 0.75 | SYK (0.48) | CDK2 | |
| SCHEMBL28693193 | 0.73 | CAMK2D (0.54) | CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114105958-B | Hydroximic acid-containing 2-phenylamino pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-11-22 | — | — | CN | disclosed |
| CN-114105958-A | Hydroximic acid-containing 2-phenylamino pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-03-01 | — | — | CN | disclosed |