Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714044 | 0.86 | TSHR (0.44) | TSHRCYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL9738786 | 0.83 | KMT2A (0.48) | TP53TSHRNPC1RAB9AMITF | |
| SCHEMBL28354626 | 0.79 | TSHR (0.49) | TP53TSHRNPC1RAB9ANCOA3 | |
| SCHEMBL28717072 | 0.77 | ALDH1A1 (0.44) | TSHRNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL28719226 | 0.76 | ALDH1A1 (0.51) | TSHRNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL28717041 | 0.76 | TSHR (0.52) | TSHRNPC1RAB9APKMCDK5 | |
| SCHEMBL28712253 | 0.74 | ALDH1A1 (0.43) | TSHRCYP3A4ALDH1A1KDM4ELMNA | |
| SCHEMBL13719456 | 0.73 | TSHR (0.49) | TP53TSHRNPC1RAB9ACYP1A2 | |
| SCHEMBL29092696 | 0.68 | NPC1 (0.43) | TP53NPC1RAB9APKMCYP1A2 | |
| SCHEMBL11179575 | 0.67 | SMN1; SMN2 (0.52) | TSHRCYP1A2CYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116903612-A | Diaryl methane derivative containing indolizine and preparation method and application thereof | 江西师范大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-115650980-A | Oxindole compound and preparation method and application thereof | 江西师范大学 | 2023-01-31 | — | — | CN | disclosed |
| CN-114163436-A | Diarylmethane derivative containing indolizine and preparation method and application thereof | 江西师范大学 | 2022-03-11 | — | — | CN | disclosed |
| CN-114105978-A | Oxindole compound and preparation method and application thereof | 江西师范大学 | 2022-03-01 | — | — | CN | disclosed |