SCHEMBL28720682

SCHEMBL28720682

Cc1cccc(C2(CCO)CO2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.46
CHRNG P07510 1/20 0.46
CHRNB1 P11230 1/20 0.46
CHRNB2 P17787 1/20 0.46
SLC6A2 P23975 1/20 0.46
CHRNB4 P30926 1/20 0.46
CHRNA3 P32297 1/20 0.46
CHRNA4 P43681 1/20 0.46
SLC6A3 Q01959 1/20 0.46
CHRND Q07001 1/20 0.46
HTR2C P28335 2/20 0.38
HDAC4 P56524 1/20 0.38
HTR2A P28223 1/20 0.38
NPSR1 Q6W5P4 2/20 0.36
LMNA P02545 1/20 0.36
ACHE P22303 2/20 0.35
HCAR2 Q8TDS4 1/20 0.35
ICMT O60725 3/20 0.35
OPRM1 P35372 1/20 0.35
OPRD1 P41143 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13360679 0.86 SLC6A2 (0.48) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL28719462 0.80 SLC6A2 (0.48) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL9802173 0.80 CHRNA1 (0.40) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL29017364 0.79 ACSS2 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL30372779 0.79 ACSS2 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL2874324 0.78 HSD11B1 (0.37) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL16089751 0.76 CHRNA1 (0.40) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL11682414 0.75 CHRNA1 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL28719471 0.74 SLC6A2 (0.40) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL30717245 0.71 CHRNA1 (0.53) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114213367-B Method for synthesizing gamma-butyrolactone by using 3, 4-epoxy-1-butanol 西北工业大学 2023-05-12 CN disclosed
CN-114213367-A Method for synthesizing gamma-butyrolactone by using 3, 4-epoxy-1-butanol 西北工业大学 2022-03-22 CN disclosed