Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878070 | 0.88 | HPGDS (0.46) | KDM4EHPGDSSMN1; SMN2ALDH1A1 | |
| SCHEMBL93597 | 0.85 | KDM4E (0.42) | KDM4EHTTLMNAL3MBTL1KDM6B | |
| SCHEMBL2876748 | 0.84 | ASAH1 (0.41) | KDM4EL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2872141 | 0.81 | ATM (0.38) | KDM4EL3MBTL1 | |
| Thiocyanic Acid SCHEMBL1615957 | 0.79 | KDM4E (0.37) | KDM4EHTTLMNAL3MBTL1KDM6B | |
| SCHEMBL821038 | 0.78 | KDM4E (0.41) | KDM4EHTTLMNAL3MBTL1KDM6B | |
| SCHEMBL8357911 | 0.75 | KDM4E (0.40) | KDM4ELMNAL3MBTL1KDM6BKDM4A | |
| SCHEMBL435395 | 0.69 | KDM4E (0.42) | KDM4EHTTLMNAL3MBTL1HSD17B10 | |
| SCHEMBL7054134 | 0.68 | KDM4E (0.38) | KDM4EHTTLMNAL3MBTL1KDM6B | |
| SCHEMBL1311500 | 0.67 | KDM4E (0.39) | KDM4EHTTLMNAL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |