SCHEMBL28721964

SCHEMBL28721964

Cc1nc(-c2ccccc2)cc2c1C(=O)N(c1ccc(I)cc1)C2=O

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 1/20 0.39
ADORA2A P29274 1/20 0.38
PIM1 P11309 2/20 0.38
HSPA1A P0DMV8 1/20 0.38
PABPC1 P11940 1/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
AR P10275 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
PDE6D O43924 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29713564 1.00 KMT2A (0.41) KMT2AMEN1ALDH1A1KDM4EADORA2A
SCHEMBL28717714 0.91 HSPA1A (0.45) KMT2AMEN1ALDH1A1KDM4EHSPA1A
SCHEMBL28704582 0.87 CASP3 (0.44) KMT2AMEN1ALDH1A1KDM4EADORA2A
SCHEMBL29713568 0.87 CASP3 (0.44) KMT2AMEN1ALDH1A1KDM4EADORA2A
SCHEMBL28715265 0.77 APP (0.42)
SCHEMBL28708191 0.76 MAPT (0.53) KMT2AMEN1ALDH1A1KDM4EADORA2A
SCHEMBL29713565 0.76 MAPT (0.53) KMT2AMEN1ALDH1A1KDM4EADORA2A
SCHEMBL31175913 0.75 CASP3 (0.63) KMT2AMEN1ALDH1A1LMNANPC1
SCHEMBL28708222 0.74 MAPT (0.50) KMT2AMEN1ALDH1A1KDM4ENPC1
SCHEMBL29713571 0.73 MAPK1 (0.56) ALDH1A1KDM4EADORA2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113480533-B Preparation method of 3, 4-pyridine diimides derivatives 赣南师范大学 2022-08-02 CN disclosed
CN-113480533-A Preparation method of 3, 4-pyridine diimides derivatives 赣南师范大学 2021-10-08 CN disclosed