Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963120 | 0.73 | TRPV4 (0.50) | TRPV4SLC22A12CYP11B1CYP11B2 | |
| SCHEMBL28724728 | 0.70 | TRPV4 (0.40) | TRPV4SLC22A12CYP11B1CYP11B2 | |
| SCHEMBL13766377 | 0.70 | TRPV4 (0.50) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL6651303 | 0.70 | TRPV4 (0.71) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL4137310 | 0.69 | KDM4E (0.44) | ALPIEPAS1 | |
| SCHEMBL30266491 | 0.67 | TRPV4 (0.47) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL10537256 | 0.67 | TRPV4 (0.47) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL15763950 | 0.67 | CA12 (0.31) | — | |
| SCHEMBL26657097 | 0.67 | TRPV4 (0.47) | TRPV4SLC22A12CYP11B1CYP11B2 | |
| SCHEMBL8895733 | 0.67 | CYP11B1 (0.46) | TRPV4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114364672-A | Benzisoxazole sulfonamide derivatives | 辉瑞大药厂 | 2022-04-15 | — | — | CN | disclosed |