Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Edelfosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | PRKCG | P05129 | 2/20 | 0.65 |
| ▸ | PRKCB | P05771 | 2/20 | 0.65 |
| ▸ | PRKCA | P17252 | 2/20 | 0.65 |
| ▸ | PRKCH | P24723 | 2/20 | 0.65 |
| ▸ | PRKCI | P41743 | 2/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.65 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edelfosine SCHEMBL28728460 | 0.98 | AKT1 (0.65) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL12380305 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| Edelfosine SCHEMBL4177817 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL8257173 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL14447847 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL23016734 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| Edelfosine SCHEMBL1962471 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| Edelfosine SCHEMBL8251942 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29464127 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL27603790 | 0.94 | AKT1 (0.73) | AKT1PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114144173-A | Analysis of materials for tissue delivery | 盖德治疗公司 | 2022-03-04 | — | — | CN | disclosed |