Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29449918 | 1.00 | MEN1 (0.53) | MEN1KMT2ADRD3HRH3HTR3A | |
| SCHEMBL30463130 | 0.95 | HRH3 (0.56) | MEN1KMT2ADRD3HRH3HTR3A | |
| SCHEMBL28731663 | 0.91 | MEN1 (0.56) | MEN1KMT2ADRD3HRH3HTR3A | |
| SCHEMBL5649077 | 0.84 | ACP1 (0.49) | MEN1KMT2AHRH3ALDH1A1MAPT | |
| SCHEMBL4965861 | 0.83 | ACP1 (0.51) | HRH3HTR7 | |
| SCHEMBL5067145 | 0.81 | MKNK1 (0.54) | KMT2AHRH3ALDH1A1USP2NPC1 | |
| SCHEMBL30117493 | 0.80 | MEN1 (0.55) | MEN1KMT2AMAPT | |
| SCHEMBL3433191 | 0.78 | TLR8 (0.55) | ALDH1A1MAPTHPGDNPC1RAB9A | |
| SCHEMBL22579036 | 0.76 | TLR8 (0.54) | MEN1KMT2AALDH1A1MAPTHPGD | |
| Phosphine SCHEMBL27716021 | 0.75 | TLR8 (0.52) | MEN1KMT2AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315802-A | Quinazoline nitrogen-containing heterocyclic derivative and preparation method and application thereof | 西安医学院 | 2022-04-12 | — | — | CN | disclosed |