Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649077 | 0.88 | ACP1 (0.49) | KDM4EALDH1A1KCNH2HRH3KMT2A | |
| SCHEMBL4965861 | 0.86 | ACP1 (0.51) | HTR2AKCNH2HRH3 | |
| SCHEMBL30463130 | 0.85 | HRH3 (0.56) | SIGMAR1ALDH1A1HRH3NPC1RAB9A | |
| SCHEMBL30117493 | 0.81 | MEN1 (0.55) | MKNK1CYP1A2KMT2ACYP2D6CYP2C19 | |
| SCHEMBL28731685 | 0.81 | MEN1 (0.53) | KDM4ESIGMAR1ALDH1A1HRH3NPC1 | |
| SCHEMBL29449918 | 0.81 | MEN1 (0.53) | KDM4ESIGMAR1ALDH1A1HRH3NPC1 | |
| SCHEMBL3399864 | 0.79 | KDM4E (0.53) | KDM4EMAPK1ALDH1A1KCNH2LMNA | |
| SCHEMBL28731663 | 0.78 | MEN1 (0.56) | MKNK1KDM4ECYP1A2ALDH1A1HRH3 | |
| SCHEMBL29937103 | 0.78 | MKNK1 (0.41) | MKNK1KDM4EALDH1A1KCNH2LMNA | |
| SCHEMBL16245396 | 0.76 | HRH3 (0.54) | KDM4EMAPK1CYP1A2SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3699191-A1 | ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF | MedImmune Limited (GB) | 2020-08-26 | — | — | EP | disclosed |
| CN-110559301-A | Compositions containing morpholinopropoxyquinazoline derivatives | 黄泳华 | 2019-12-13 | — | — | CN | disclosed |
| CN-110559301-A | Compositions containing morpholinopropoxyquinazoline derivatives | 黄泳华 | 2019-12-13 | — | — | CN | disclosed |
| US-10066011-B2 | Antibodies directed to angiopoietin-2 and uses thereof | MEDIMMUNE LIMITED (GB) | 2018-09-04 | — | — | US | disclosed |
| EP-3204360-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20150125455-A1 | ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF | ABGENIX, INC. | 2015-05-07 | — | — | US | disclosed |
| US-8834880-B2 | Antibodies directed to angiopoietin-2 and uses thereof | MEDIMMUNE LIMITED (GB) | 2014-09-16 | — | — | US | disclosed |
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| US-20130171160-A1 | ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF | MEDIMMUNE LIMITED (GB) | 2013-07-04 | — | — | US | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |
| US-20080267971-A1 | Antibodies Directed to Angiopoietin-2 and Uses Thereof | MEDIMMUNE LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| EP-1838733-A2 | ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-20060246071-A1 | Antibodies directed to angiopoietin-2 and uses thereof | MEDIMMUNE LIMITED (GB) | 2006-11-02 | — | — | US | disclosed |
| WO-2006068953-A2 | ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |