Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30463130 | 0.93 | HRH3 (0.56) | MEN1KMT2AMAPTHTR3AHRH4 | |
| SCHEMBL28731685 | 0.91 | MEN1 (0.53) | MEN1KMT2AMAPTHTR3AHRH4 | |
| SCHEMBL29449918 | 0.91 | MEN1 (0.53) | MEN1KMT2AMAPTHTR3AHRH4 | |
| SCHEMBL30117493 | 0.89 | MEN1 (0.55) | MEN1KMT2AMAPTLTA4HMKNK1 | |
| SCHEMBL5649077 | 0.82 | ACP1 (0.49) | MEN1KMT2AMAPTHRH3LTA4H | |
| SCHEMBL4965861 | 0.81 | ACP1 (0.51) | HRH3LTA4H | |
| SCHEMBL5067145 | 0.78 | MKNK1 (0.54) | KMT2AHRH3MKNK1KDM4EALDH1A1 | |
| SCHEMBL7882926 | 0.77 | HTR3A (0.49) | HTR3AHRH4HRH3 | |
| SCHEMBL7044155 | 0.76 | TLR8 (0.51) | MEN1KMT2AMAPTHTR3AHRH4 | |
| SCHEMBL716117 | 0.74 | TSHR (0.50) | HTR3AHRH4KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315802-B | Quinazoline nitrogen-containing heterocyclic derivative, preparation method and application | 西安医学院 | 2023-06-16 | — | — | CN | disclosed |
| CN-114315802-A | Quinazoline nitrogen-containing heterocyclic derivative and preparation method and application thereof | 西安医学院 | 2022-04-12 | — | — | CN | disclosed |