Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28734414 | 0.73 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL28734418 | 0.73 | PIK3CD (0.36) | CYP2A6METAP2TGFBR1PLK1PLK2 | |
| SCHEMBL29722165 | 0.73 | PIK3CD (0.36) | CYP2A6METAP2TGFBR1PLK1PLK2 | |
| SCHEMBL29722082 | 0.73 | TGFBR1 (0.41) | TGFBR1TGFBR2 | |
| SCHEMBL28734413 | 0.72 | TGFBR1 (0.37) | CYP2A6CCR1CCR8CYP11B1CYP11B2 | |
| SCHEMBL29721948 | 0.71 | PIK3CD (0.35) | CYP2A6CYP11B1CYP11B2ADORA2AADORA1 | |
| SCHEMBL28734453 | 0.71 | TGFBR1 (0.36) | CYP2A6ADORA2AADORA1TGFBR1PLK1 | |
| SCHEMBL3780127 | 0.70 | BRPF1 (0.43) | BRPF1PIK3CAMTORRPTORMLST8 | |
| SCHEMBL17813459 | 0.68 | MTOR (0.37) | BRPF1PIK3CAMTORRPTORMLST8 | |
| SCHEMBL12405339 | 0.67 | BRPF1 (0.57) | BRPF1CYP11B1CYP11B2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380845-A | Heterocyclic-fused compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-04-22 | — | — | CN | disclosed |