Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 9/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738241 | 1.00 | SPPL2A (0.51) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738352 | 0.86 | BACE1 (0.52) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738317 | 0.86 | SPPL2A (0.48) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738351 | 0.86 | BACE1 (0.52) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738316 | 0.86 | SPPL2A (0.48) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738314 | 0.73 | SPPL2A (0.51) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28738312 | 0.73 | SPPL2A (0.51) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14390723 | 0.72 | SPPL2A (0.54) | SPPL2AF2ALDH1A1MAPT | |
| SCHEMBL20839243 | 0.72 | HDAC8 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20847632 | 0.70 | HDAC8 (0.74) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230630-B | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2024-03-08 | — | — | CN | disclosed |
| CN-114230630-A | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2022-03-25 | — | — | CN | disclosed |