Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | SPPL2A | Q8TCT8 | 5/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738351 | 1.00 | BACE1 (0.52) | BACE1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL28738239 | 0.86 | SPPL2A (0.51) | BACE1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL28738241 | 0.86 | SPPL2A (0.51) | BACE1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL28738316 | 0.83 | SPPL2A (0.48) | BACE1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL28738317 | 0.83 | SPPL2A (0.48) | BACE1SPPL2APSEN1PSEN2APH1B | |
| SCHEMBL4872869 | 0.82 | KCNA5 (0.50) | BACE1SPPL2AKCNA5MMP1MMP9 | |
| SCHEMBL7905239 | 0.81 | SPPL2A (0.69) | SPPL2A | |
| SCHEMBL28628359 | 0.81 | SPPL2A (0.60) | SPPL2AKEAP1 | |
| SCHEMBL14602719 | 0.81 | SPPL2A (0.69) | SPPL2A | |
| SCHEMBL28628358 | 0.81 | SPPL2A (0.60) | SPPL2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230630-A | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2022-03-25 | — | — | CN | disclosed |