Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.76 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 4/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911140 | 1.00 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1051190 | 0.94 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10031792 | 0.94 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL608142 | 0.94 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9605440 | 0.94 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23129692 | 0.94 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1054059 | 0.93 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL14637729 | 0.93 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL14636197 | 0.93 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16727690 | 0.93 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877474-B1 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS LTD (IN) | 2020-11-04 | — | — | EP | claimed |
| EP-2877474-A2 | A PROCESS FOR PREPARATION OF DARUNAVIR | Laurus Labs Private Limited (IN) | 2015-06-03 | — | — | EP | claimed |
| WO-2014016660-A2 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS PRIVATE LIMITED (IN) | 2014-01-30 | — | — | WO | claimed |
| EP-3795572-B1 | DARUNAVIR PROPIONATE SOLVATE | LAURUS LABS LTD (IN) | 2023-11-15 | — | — | EP | disclosed |
| EP-3795572-A1 | DARUNAVIR PROPIONATE SOLVATE | Laurus Labs Limited (IN) | 2021-03-24 | — | — | EP | disclosed |
| EP-2877474-B1 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS LTD (IN) | 2020-11-04 | — | — | EP | disclosed |
| EP-2877474-B1 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS LTD (IN) | 2020-11-04 | — | — | EP | disclosed |
| EP-2477992-B1 | PROCESSES FOR THE PREPARATION OF DARUNAVIR AND THE AMORPHOUS FORM THEREOF | MYLAN LABORATORIES LTD (IN) | 2016-12-14 | — | — | EP | disclosed |
| US-20160355525-A1 | PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS LIMITED (IN) | 2016-12-08 | — | — | US | disclosed |
| EP-2877474-A2 | A PROCESS FOR PREPARATION OF DARUNAVIR | Laurus Labs Private Limited (IN) | 2015-06-03 | — | — | EP | disclosed |
| US-8703980-B2 | Process for the preparation of darunavir | TIANISH LABORATORIES PRIVATE LIMITED (IN) | 2014-04-22 | — | — | US | disclosed |
| WO-2014016660-A2 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS PRIVATE LIMITED (IN) | 2014-01-30 | — | — | WO | disclosed |
| WO-2013114382-A1 | CRYSTALLINE DARUNAVIR | MYLAN LABORATORIES LTD (IN) | 2013-08-08 | — | — | WO | disclosed |
| WO-2013011485-A1 | PROCESS FOR THE PREPARATION OF SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2013-01-24 | — | — | WO | disclosed |
| CN-1898248-B | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate | TIBOTEC PHARM LTD | 2011-08-17 | — | — | CN | disclosed |
| EP-1725566-B1 | PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | TIBOTEC PHARM LTD (IE) | 2009-06-17 | — | — | EP | disclosed |
| CN-1898248-A | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate | TIBOTEC PHARM LTD (IE) | 2007-01-17 | — | — | CN | disclosed |
| EP-1725566-A1 | PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | Tibotec Pharmaceuticals Ltd. (IE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005063770-A1 | PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355525-A1 | PROCESS FOR PREPARATION OF DARUNAVIR | SAMHD1, CYP3A5, DARS1 | SPPL2A 4665/4885PSEN1 3308/4885PSEN2 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.