SCHEMBL28742425

SCHEMBL28742425

COc1ccccc1/C=C/CNCC(O)COc1ccc(Cc2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 6/20 0.46
ADRB1 P08588 5/20 0.46
ADRB3 P13945 4/20 0.46
S1PR1 P21453 1/20 0.45
CASR P41180 3/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28742429 1.00 ADRB2 (0.46) ADRB2ADRB1ADRB3S1PR1CASR
SCHEMBL29670166 0.91 ADRB2 (0.48) ADRB2ADRB1ADRB3CASRKMT2A
SCHEMBL30483437 0.89 KDM1A (0.55) ADRB2ADRB1ADRB3S1PR1KMT2A
SCHEMBL29670184 0.89 ADRB3 (0.48) ADRB2ADRB1ADRB3S1PR1CASR
SCHEMBL29670261 0.88 ADRB1 (0.51) ADRB2ADRB1ADRB3KMT2A
SCHEMBL29670116 0.85 KDM1A (0.57) ADRB2ADRB1ADRB3S1PR1CASR
SCHEMBL29670264 0.85 ADRB2 (0.43) ADRB2ADRB1ADRB3KMT2AMEN1
SCHEMBL29670104 0.82 ADRB2 (0.45) ADRB2ADRB1ADRB3S1PR1KMT2A
SCHEMBL29670110 0.82 ADRB1 (0.47) ADRB2ADRB1ADRB3S1PR1KMT2A
SCHEMBL29669995 0.80 KDM1A (0.46) ADRB2ADRB1ADRB3S1PR1CASR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114539129-B Allylamine bifunctional compound and application thereof 上海中医药大学附属龙华医院 2023-06-09 CN claimed
CN-114539129-A Allylamine bifunctional compound and application thereof 上海中医药大学附属龙华医院 2022-05-27 CN claimed
CN-114539129-A Allylamine bifunctional compound and application thereof 上海中医药大学附属龙华医院 2022-05-27 CN disclosed