Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29499586 | 1.00 | MAPK1 (0.50) | MAPK1EGFRMAPK14MAPK8MAPK3 | |
| SCHEMBL28744849 | 0.87 | MAPK14 (0.43) | MAPK1MAPK14MAPK8P2RX3P2RX2 | |
| SCHEMBL29499563 | 0.87 | MAPK1 (0.49) | MAPK1MAPK14MAPK8MAPK3P2RX3 | |
| SCHEMBL28744833 | 0.87 | MAPK1 (0.49) | MAPK1MAPK14MAPK8MAPK3P2RX3 | |
| SCHEMBL29499574 | 0.87 | MAPK14 (0.43) | MAPK1MAPK14MAPK8P2RX3P2RX2 | |
| SCHEMBL29499565 | 0.84 | ULK1 (0.48) | MAPK1MAPK14MAPK3 | |
| SCHEMBL28744859 | 0.84 | ULK1 (0.48) | MAPK1MAPK14MAPK3 | |
| SCHEMBL28744841 | 0.80 | MAPK1 (0.56) | MAPK1MAPK3PLK4 | |
| SCHEMBL29499572 | 0.80 | MAPK1 (0.56) | MAPK1MAPK3PLK4 | |
| SCHEMBL29499591 | 0.78 | MAPK1 (0.49) | MAPK1MAPK14MAPK3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276331-B | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114276331-A | 4-aminopiperidine compound and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2022-04-05 | — | — | CN | disclosed |