Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 12/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.47 |
| ▸ | RAC1 | P63000 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15887346 | 0.89 | ALDH1A1 (0.63) | ALDH1A1GAAALOX12HTTHIF1A | |
| SCHEMBL4129677 | 0.85 | AKR1C3 (0.47) | ALDH1A1HIF1AHPGDHSD17B10AKR1C3 | |
| SCHEMBL1002973 | 0.85 | AKR1C3 (0.50) | ALDH1A1HIF1AHPGDHSD17B10AKR1C3 | |
| SCHEMBL32660739 | 0.82 | TDP1 (0.55) | GAAHIF1AALOX15HSD17B10AKR1C3 | |
| SCHEMBL490579 | 0.82 | TDP1 (0.55) | GAAHIF1AALOX15HSD17B10AKR1C3 | |
| SCHEMBL28183228 | 0.81 | TDP1 (0.53) | GAAHIF1AALOX15HSD17B10AKR1C3 | |
| SCHEMBL31430560 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAAALOX12HTTHIF1A | |
| SCHEMBL11216724 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAAALOX12HTTHIF1A | |
| SCHEMBL732665 | 0.80 | AKR1C3 (0.55) | HIF1AHPGDAKR1C3AKR1C2PTGS2 | |
| SCHEMBL30526268 | 0.79 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034017-A1 | 4-fluoroalkyl-2h-benzopyrans anti-estogenic activity | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-02-19 | — | — | US | claimed |
| EP-0062440-A1 | Process for preparing phenylalkanoic acids and derivatives of benzoxazole therefrom | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | claimed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | claimed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2427436-B1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2013-01-09 | — | — | EP | disclosed |
| US-8334315-B2 | Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2012-12-18 | — | — | US | disclosed |
| EP-2427436-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | disclosed |
| US-8084484-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| EP-1688413-A1 | Benzoxazole derivatives for the prophylaxis and treatment of inflammatory bowel diseases | Hikma Pharmaceuticals Co. Ltd. (JO) | 2006-08-09 | — | — | EP | disclosed |
| US-20040209776-A1 | Azole derivatives useful as insecticide | FAROOQ SALEEM | 2004-10-21 | — | — | US | disclosed |
| US-6703347-B2 | INSECTICIDES, FUNGICIDES, NEMATOCIDES, MOLLUSCICIDES, AND MITICIDES FOR PLANTS | SYNGENTA LIMITED (GB) | 2004-03-09 | — | — | US | disclosed |
| EP-0293091-B1 | POLY(AMIDE-BENZAZOLES) | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-01-13 | — | — | EP | disclosed |
| US-4816554-A | HEAT RESISTANT POLYMERS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| EP-0293091-A1 | Poly(amide-benzazoles) | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| EP-0062440-A1 | Process for preparing phenylalkanoic acids and derivatives of benzoxazole therefrom | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | disclosed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209776-A1 | Azole derivatives useful as insecticide | CYP8B1, HRH2, API5 | ALDH1A1 1410/4885GAA 3356/4885ALOX12 3084/4885 |
| US-20040034017-A1 | 4-fluoroalkyl-2h-benzopyrans anti-estogenic activity | ESR2, CYP19A1, GPER1 | ALDH1A1 758/4885GAA 445/4885ALOX12 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.