Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851267 | 0.98 | PTGS2 (0.43) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7845555 | 0.97 | PTGS2 (0.42) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| Nitric Acid SCHEMBL4138682 | 0.90 | PTGS2 (0.54) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL4128980 | 0.88 | PTGS2 (0.56) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4120907 | 0.87 | PTGS2 (0.55) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4134235 | 0.87 | HPGD (0.42) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7839947 | 0.79 | KDM4E (0.40) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7130432 | 0.77 | PTGS2 (0.59) | PTGS2MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7828216 | 0.77 | PTGS2 (0.44) | PTGS2LMNAKDM4EALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7828218 | 0.76 | PTGS2 (0.43) | PTGS2LMNAKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1342147-A | Nitrooxyderivatives having anti-inflammatory, analgesic and antithrombotic activity | NICOX SA (FR) | 2002-03-27 | — | — | CN | disclosed |