Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29633186 | 0.80 | NTRK1 (0.53) | MKNK1MKNK2AR | |
| SCHEMBL13617393 | 0.78 | MKNK1 (0.62) | MKNK1MKNK2CHEK2RIPK1CAMKK2 | |
| SCHEMBL4631461 | 0.77 | PRKCI (0.54) | CHEK2PRKCIPARP1 | |
| SCHEMBL7114095 | 0.75 | L3MBTL1 (0.59) | PARP1 | |
| SCHEMBL30903715 | 0.74 | L3MBTL1 (0.52) | MKNK1MKNK2CHEK2PARP1 | |
| SCHEMBL2026663 | 0.74 | L3MBTL1 (0.52) | MKNK1MKNK2CHEK2PARP1 | |
| Hydrochloric Acid SCHEMBL28812686 | 0.73 | CHEK2 (0.50) | MKNK1MKNK2CHEK2PARP1 | |
| SCHEMBL27863850 | 0.73 | CHEK2 (0.60) | MKNK1MKNK2ARCHEK2 | |
| SCHEMBL10643828 | 0.73 | CHEK2 (0.56) | MKNK1MKNK2CHEK2PARP1 | |
| SCHEMBL19241426 | 0.72 | HCRTR1 (0.48) | MKNK1MKNK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108495855-B | Fused thiazolopyrimidine derivatives as MNK inhibitors | 生命弧度公司 | 2022-05-31 | — | — | CN | disclosed |