Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110477 | 0.86 | NTRK1 (0.50) | NTRK1PDK2KMO | |
| SCHEMBL17110465 | 0.84 | NTRK1 (0.47) | NTRK1KMO | |
| SCHEMBL18748544 | 0.82 | NTRK1 (0.50) | NTRK1KMO | |
| SCHEMBL17110505 | 0.81 | NOTUM (0.58) | NTRK1PDK2 | |
| SCHEMBL28750643 | 0.80 | MKNK1 (0.53) | ARMKNK1MKNK2 | |
| SCHEMBL18131149 | 0.76 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL29633201 | 0.76 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL2709797 | 0.76 | AR (0.45) | ARPDK2MAOB | |
| SCHEMBL449719 | 0.75 | MKNK1 (0.43) | NTRK1PDK2MAOBMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL27741712 | 0.74 | AR (0.44) | ARPDK2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | disclosed |