SCHEMBL28753530

SCHEMBL28753530

O=CCl.O=[N+]([O-])c1ccc(F)c(Cl)c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.44
TSHR P16473 2/20 0.43
MAPK1 P28482 1/20 0.43
ATM Q13315 1/20 0.43
ALDH1A1 P00352 5/20 0.42
HIF1A Q16665 2/20 0.42
VCAM1 P19320 3/20 0.40
CASP6 P55212 1/20 0.39
POLB P06746 2/20 0.38
MAPT P10636 2/20 0.38
CYP3A4 P08684 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
TXNRD1 Q16881 1/20 0.37
TXNRD3 Q86VQ6 1/20 0.37
TXNRD2 Q9NNW7 1/20 0.37
LMNA P02545 1/20 0.35
PIN1 Q13526 1/20 0.35
GPR35 Q9HC97 1/20 0.34
HTR2A P28223 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308086 0.93 TDP1 (0.50) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL29705108 0.93 TDP1 (0.50) TDP1TSHRMAPK1ATMALDH1A1
Formic Acid SCHEMBL27537874 0.91 TDP1 (0.43) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL29940081 0.79 TDP1 (0.63) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL2551163 0.79 TDP1 (0.63) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL29137985 0.79 TDP1 (0.44) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL29435969 0.77 TDP1 (0.67) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL31342321 0.77 TDP1 (0.55) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL4603872 0.77 TDP1 (0.67) TDP1TSHRMAPK1ATMALDH1A1
SCHEMBL3723529 0.77 TDP1 (0.55) TDP1TSHRMAPK1ATMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1671690-A Antimicrobial azabicyclic derivatives, compositions and uses thereof PROCTER & GAMBLE (US) 2005-09-21 CN disclosed