Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.41 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29705108 | 1.00 | TDP1 (0.50) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL28753530 | 0.93 | TDP1 (0.44) | TDP1TSHRMAPK1ATMALDH1A1 | |
| Formic Acid SCHEMBL27537874 | 0.91 | TDP1 (0.43) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL2551163 | 0.85 | TDP1 (0.63) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL29940081 | 0.85 | TDP1 (0.63) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL4603872 | 0.83 | TDP1 (0.67) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL29435969 | 0.83 | TDP1 (0.67) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL3723529 | 0.83 | TDP1 (0.55) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL31342321 | 0.83 | TDP1 (0.55) | TDP1TSHRMAPK1ATMALDH1A1 | |
| SCHEMBL10526798 | 0.82 | TDP1 (0.48) | TDP1TSHRMAPK1ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801429-B | A kind of preparation method of the chloro- 2,4 difluorobenzene amine of 3,5- bis- | 安徽新北卡化学有限公司 | 2019-09-24 | — | — | CN | claimed |
| CN-109369414-A | A method of preparing the chloro- 2,4 difluorobenzene amine of Teflubenzuron intermediate 3,5- bis- | 江苏中旗科技股份有限公司 | 2019-02-22 | — | — | CN | claimed |
| CN-105801429-A | Preparation method for 3,5,-dichloro-2,4,-difluoroaniline | 上海北卡医药技术有限公司 | 2016-07-27 | — | — | CN | claimed |
| CN-102617360-A | Synthetic method of 3, 5-dichloro-2, 4-difluoroaniline | JIANGXI JIXIANG PHARMACEUTICAL CO LTD | 2012-08-01 | — | — | CN | claimed |
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | claimed |
| CN-1267402-C | Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron | UNIV ZHEJIANG TECHNOLOGY (CN) | 2006-08-02 | — | — | CN | claimed |
| CN-1683318-A | Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-10-19 | — | — | CN | claimed |
| US-20030153750-A1 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors | PLIVA FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO | 2003-08-14 | — | — | US | claimed |
| EP-1284977-A1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2003-02-26 | — | — | EP | claimed |
| WO-2001087890-A1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | PLIVA, FARMACEUTSKA INDUSTRIJA, DIONIKO DRUSTVO (HR) | 2001-11-22 | — | — | WO | claimed |
| EP-0667337-B1 | Method for preparing fluoroanilines | CLARIANT GMBH (DE) | 1998-01-21 | — | — | EP | claimed |
| US-5498794-A | Process for preparing fluoroanilines | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-03-12 | — | — | US | claimed |
| EP-0667337-A1 | Method for preparing fluoroanilines | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-16 | — | — | EP | claimed |
| US-5294742-A | Process for preparing 3,5-difluoroaniline | HOECHST ATKIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | claimed |
| US-5066802-A | Multistep process from 2,4-difluoro-3-chloronitrobenzene and mercaptoisopropanol or mercaptopropanediol | MEDIOLANUM FARMACEUTICI SRL. (IT) | 1991-11-19 | — | — | US | claimed |
| US-4868299-A | Antibacterially active pyrido-benzothiazine derivatives with long-term action | MEDIOLANUM FARMACEUTICI SRL (IT) | 1989-09-19 | — | — | US | claimed |
| EP-0310969-A2 | Pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1989-04-12 | — | — | EP | claimed |
| JP-3090057-A | — | — | None | — | — | JP | disclosed |
| EP-0001825-A1 | Method of preparing 2,4-difluoroaniline | MERCK & CO. INC. (US) | 1979-05-16 | — | — | EP | disclosed |
| US-4140719-A | Solid-liquid phase transfer catalysis improved method of preparing 2,4-difluoroaniline | MERCK & CO., INC. (US) | 1979-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153750-A1 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors | TNF, IL1B, IL1A | TDP1 1710/4885TSHR 2774/4885MAPK1 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.