Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11874817 | 0.82 | LTA4H (0.68) | LTA4HALDH1A1MAPTKCNA5SYK | |
| SCHEMBL28228124 | 0.81 | NPC1 (0.54) | ALDH1A1MAPTMAPK1L3MBTL1HRH3 | |
| SCHEMBL11880128 | 0.79 | LTA4H (0.56) | LTA4HALDH1A1MAPTSYKHRH3 | |
| SCHEMBL3436048 | 0.78 | POLB (0.55) | LTA4HDRD3ALDH1A1MAPTADRA1A | |
| SCHEMBL19462908 | 0.78 | LTA4H (0.64) | LTA4HDRD3ALDH1A1MAPTKCNA5 | |
| SCHEMBL21697458 | 0.76 | KCNA5 (0.48) | DRD3ALDH1A1MAPTKCNA5SYK | |
| SCHEMBL9122265 | 0.75 | LTA4H (0.77) | LTA4HALDH1A1MAPTKCNA5MEN1 | |
| SCHEMBL211606 | 0.75 | LTA4H (0.77) | LTA4HALDH1A1MAPTKCNA5MEN1 | |
| SCHEMBL7445795 | 0.74 | POLB (0.75) | LTA4HALDH1A1SYKMEN1KMT2A | |
| SCHEMBL13605386 | 0.74 | MCHR1 (0.50) | LTA4HDRD3SYKHRH3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |