Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28754443 | 1.00 | HCAR3 (0.46) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL29157052 | 0.88 | HCAR3 (0.35) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL25404705 | 0.86 | KMT2A (0.40) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL31463429 | 0.86 | KMT2A (0.40) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL25279173 | 0.86 | KMT2A (0.40) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL29157312 | 0.86 | HCAR3 (0.46) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL29157314 | 0.86 | HCAR3 (0.46) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL26668997 | 0.85 | HCAR3 (0.44) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL29160144 | 0.85 | HCAR3 (0.46) | HCAR3KMT2AHPGDCYP2C9CYP1A2 | |
| SCHEMBL29160143 | 0.85 | HCAR3 (0.46) | HCAR3KMT2AHPGDCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103366-A | Certain 2, 5-diazabicyclo [4.2.0] octanes as GLP-1 receptor modulators | 阿斯利康(瑞典)有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117295729-A | Carboxy-benzimidazole GLP-1R modulating compounds | 吉利德科学公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-117279905-A | Carboxy-benzimidazole GLP-1R modulating compounds | 吉利德科学公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117242067-A | Novel aryl ether substituted heterocycles as GLP1R agonists | 杭州德睿智药科技有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-117177970-A | Polycyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-115521297-A | 5,6-dihydro-1,2,4-triazines and their pharmaceutical use as GLP-1 receptor agonists | 中国科学院上海药物研究所 | 2022-12-27 | — | — | CN | disclosed |
| CN-115335374-A | GLP-1R modulating compounds | 吉利德科学公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-114716423-A | 5, 6-dihydro-1, 2, 4-triazines and their pharmaceutical use as GLP-1 receptor agonists | 中国科学院上海药物研究所 | 2022-07-08 | — | — | CN | disclosed |
| CN-114630823-A | GLP-1R modulating compounds | 吉利德科学公司 | 2022-06-14 | — | — | CN | disclosed |