Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514569 | 0.77 | OPRL1 (0.55) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL20315440 | 0.73 | OPRL1 (0.49) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL7784244 | 0.73 | HTR2A (0.51) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL4689150 | 0.73 | OPRL1 (0.49) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL24736536 | 0.72 | OPRL1 (0.48) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL20757766 | 0.72 | CHRNB2 (0.59) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL3336712 | 0.72 | SLC6A4 (0.50) | HTR2AHTR2CSLC6A4HTR2BOPRL1 | |
| SCHEMBL3753381 | 0.71 | DPP4 (0.60) | HTR2AHTR2CSLC6A4HTR2BKDM1A | |
| SCHEMBL3753384 | 0.71 | DPP4 (0.60) | HTR2AHTR2CSLC6A4HTR2BKDM1A | |
| SCHEMBL3753386 | 0.71 | DPP4 (0.60) | HTR2AHTR2CSLC6A4HTR2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1659144-B | Quinoline and isoquinoline derivatives, process for their preparation and their use as inflammation inhibitors | SCHERING AG | 2010-09-08 | — | — | CN | disclosed |
| CN-1659144-A | Quinoline and isoquinoline derivatives, process for their preparation and their use as inflammation inhibitors | SCHERING AG (DE) | 2005-08-24 | — | — | CN | disclosed |