Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25330838 | 0.82 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL5631034 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL13878884 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL14380823 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL28575662 | 0.74 | ACE (0.47) | ALDH1A1KMT2A | |
| SCHEMBL17844739 | 0.73 | CA12 (0.47) | KMT2A | |
| SCHEMBL17844742 | 0.73 | CA12 (0.47) | KMT2A | |
| SCHEMBL6500698 | 0.73 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL13878882 | 0.72 | GSTP1 (0.52) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL552157 | 0.71 | LMNA (0.51) | ALDH1A1LMNAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100384852-C | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2008-04-30 | — | — | CN | disclosed |
| CN-1653070-A | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2005-08-10 | — | — | CN | disclosed |