SCHEMBL28755128

SCHEMBL28755128

COc1ccc(C=Cc2ccc(O)c(=O)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 3/20 0.66
NQO2 P16083 2/20 0.66
NFE2L2 Q16236 2/20 0.62
PTGS2 P35354 3/20 0.59
KDM4E B2RXH2 3/20 0.59
PTGS1 P23219 2/20 0.59
CYP1A1 P04798 2/20 0.59
CYP1B1 Q16678 2/20 0.59
LMNA P02545 2/20 0.59
ALOX12 P18054 1/20 0.59
TRPA1 O75762 1/20 0.55
F3 P13726 1/20 0.55
ALOX5 P09917 2/20 0.54
ESR1 P03372 2/20 0.53
AHR P35869 2/20 0.53
CYP1A2 P05177 2/20 0.53
ABL1 P00519 1/20 0.53
TTR P02766 1/20 0.53
ABCB1 P08183 1/20 0.53
BCR P11274 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23250710 0.88 HDAC4 (0.56) RELANQO2KDM4ETHRBALDH1A1
SCHEMBL631998 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL699457 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL13790336 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL4881152 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL699458 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL14950253 0.79 RELA (0.81) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL5495966 0.79 NQO2 (1.00) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL5495964 0.79 NQO2 (1.00) RELANQO2NFE2L2PTGS2KDM4E
SCHEMBL30940357 0.79 NQO2 (1.00) RELANQO2NFE2L2PTGS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109562050-B Gel-like composition 株式会社钟化 2022-05-10 CN disclosed