Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 12/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 12/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 0.37 |
| ▸ | CHRM4 known ✓ | P08173 | 10/20 | 0.35 |
| ▸ | CHRM5 known ✓ | P08912 | 10/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2868382 | 1.00 | CHRM2 (0.37) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Bromide SCHEMBL2868385 | 1.00 | CHRM2 (0.37) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL1109778 | 0.99 | CHRM2 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL1109777 | 0.99 | CHRM2 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL13329491 | 0.99 | CHRM2 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Bromide SCHEMBL2879541 | 0.93 | HRH1 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| Bromide SCHEMBL2879542 | 0.93 | HRH1 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL1109809 | 0.93 | HRH1 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL1109807 | 0.93 | HRH1 (0.38) | CHRM2CHRM1KCNH2CYP2D6CHRM3 | |
| SCHEMBL1109770 | 0.92 | HRH1 (0.39) | CHRM2CHRM1KCNH2CYP2D6CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277275-A1 | AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-11-01 | — | — | US | disclosed |
| EP-1924570-B1 | AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE | PULMAGEN THERAPEUTICS SYNERGY (GB) | 2010-10-20 | — | — | EP | disclosed |
| US-20100113540-A1 | Azole and Thiazole Derivatives and Their Use | ARGENTA DISCOVERY LIMITED (GB) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113540-A1 | Azole and Thiazole Derivatives and Their Use | CHRM3, CHRM2, CHRM1 | CHRM2 2/4885CHRM1 3/4885CHRM3 1/4885 |
| US-20120277275-A1 | AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE | CHRM3, GPR65, GPR34 | CHRM2 12/4885CHRM1 24/4885CHRM3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.