Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17934 | 0.89 | TSHR (0.59) | TSHRGPR35TDP1SMN1; SMN2PDE7A | |
| Hydrochloric Acid SCHEMBL8040214 | 0.87 | TSHR (0.57) | TSHRGPR35TDP1SMN1; SMN2PDE7A | |
| SCHEMBL1247314 | 0.82 | GPR35 (0.45) | TSHRGPR35TDP1L3MBTL1SMN1; SMN2 | |
| Acetone SCHEMBL27830389 | 0.81 | TSHR (0.64) | TSHRGPR35TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2646463 | 0.77 | ALDH1A1 (0.42) | TSHRGPR35TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8477874 | 0.77 | TDP1 (0.53) | TSHRGPR35TDP1L3MBTL1SMN1; SMN2 | |
| Methylamine SCHEMBL28414354 | 0.77 | TSHR (0.69) | TSHRGPR35TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL11551067 | 0.77 | TDP1 (0.52) | TSHRGPR35TDP1SMN1; SMN2PDE7A | |
| SCHEMBL3390153 | 0.77 | TDP1 (0.52) | TSHRGPR35TDP1SMN1; SMN2PDE7A | |
| SCHEMBL28529002 | 0.77 | TSHR (0.68) | TSHRGPR35TDP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056644-A1 | 1- (ARYLSULFONYL) -4- (PI PERAZIN-I -YL) -IH-BENZ IMIDAZOLES AS δ-HYDROXYTRYPTAMINE- 6 LIGANDS | WYETH LLC (US) | 2010-05-20 | — | — | WO | disclosed |