Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21262770 | 0.78 | RAB9A (0.60) | ALOX15HPGDMAPTSMN1; SMN2RAB9A | |
| SCHEMBL19998612 | 0.75 | SMN1; SMN2 (0.56) | ALOX15HPGDMAPTSMN1; SMN2RAB9A | |
| SCHEMBL13929106 | 0.72 | HSD17B10 (0.69) | ALOX15HPGDMAPTSMN1; SMN2RAB9A | |
| SCHEMBL4895919 | 0.72 | KDM4E (0.50) | ALOX15HPGDMAPTSMN1; SMN2RAB9A | |
| SCHEMBL10118731 | 0.70 | TNIK (0.55) | MAPTSMN1; SMN2HSD17B10LMNANPSR1 | |
| SCHEMBL1773863 | 0.70 | RAB9A (0.61) | HPGDMAPTSMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL2919461 | 0.70 | MAPT (0.52) | MAPTSMN1; SMN2RAB9AUSP2TSHR | |
| SCHEMBL5559897 | 0.69 | HPGD (0.38) | ALOX15HPGDMAPTSMN1; SMN2RAB9A | |
| SCHEMBL23603399 | 0.69 | BRD4 (0.49) | ALOX15HSD17B10ALDH1A1ALOX12KDM4E | |
| SCHEMBL7457669 | 0.69 | KMT2A (0.62) | HPGDMAPTSMN1; SMN2RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1802373-A | Pyrazoloisoquinoline derivatives as kinase inhibitors | AVENTIS PHARMA INC (US) | 2006-07-12 | — | — | CN | claimed |
| CN-1802373-A | Pyrazoloisoquinoline derivatives as kinase inhibitors | AVENTIS PHARMA INC (US) | 2006-07-12 | — | — | CN | disclosed |