Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12086639 | 0.79 | ALOX12 (0.55) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL27973945 | 0.78 | ALOX12 (0.47) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL25946601 | 0.77 | ALOX12 (0.41) | ALOX12SIGMAR1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12269439 | 0.76 | NPSR1 (0.44) | NPSR1HTTLMNAL3MBTL1POLB | |
| SCHEMBL21882889 | 0.75 | UTS2R (0.46) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL9342946 | 0.74 | ALOX12 (0.49) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL12086597 | 0.72 | GAA (0.49) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL29439376 | 0.72 | NPSR1 (0.40) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL13253339 | 0.71 | NPSR1 (0.57) | ALOX12NPSR1HTTLMNAL3MBTL1 | |
| SCHEMBL27971438 | 0.71 | NPSR1 (0.47) | NPSR1HTTLMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102617464-A | fused compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor | ABBOTT LAB | 2012-08-01 | — | — | CN | disclosed |
| CN-101445501-A | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor | ABBOTT LAB (US) | 2009-06-03 | — | — | CN | disclosed |
| CN-1835924-A | Fused compounds that inhibit vanilloid receptor subtype 1(vr1) receptor | ABBOTT LAB (US) | 2006-09-20 | — | — | CN | disclosed |