Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.82 |
| ▸ | AXL | P30530 | 2/20 | 0.82 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 6/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | CHUK | O15111 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431037 | 0.91 | PRKCI (1.00) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL100651 | 0.91 | PRKCI (1.00) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL11889555 | 0.77 | PRKCI (0.72) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL2240671 | 0.70 | AURKB (0.71) | PRKCIAXLJAK2NUDT1IKBKB | |
| SCHEMBL4793014 | 0.69 | IGF1R (0.63) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL12613153 | 0.69 | PRKCI (0.61) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL12127566 | 0.69 | NUDT1 (0.61) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL1036770 | 0.68 | PRKCI (0.55) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL3339974 | 0.67 | PRKCI (0.59) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL21062776 | 0.67 | PRKCI (0.59) | PRKCIAXLJAK2JAK1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509811-C | Azaindoles | AVENTIS PHARMA LTD (GB) | 2009-07-08 | — | — | CN | disclosed |
| CN-1665809-A | Azaindoles | AVENTIS PHARMA LTD (GB) | 2005-09-07 | — | — | CN | disclosed |