Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 13/20 | 0.49 |
| ▸ | HTR1D | P28221 | 11/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 11/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27752472 | 0.81 | LTA4H (0.57) | HTR1BHTR1DKDM4ECYP1A2CYP3A4 | |
| SCHEMBL27623612 | 0.80 | KDM4E (0.54) | KDM4ECYP1A2HTR2AMAPK1 | |
| SCHEMBL27596759 | 0.80 | HTR1D (0.46) | HTR1BHTR1D | |
| SCHEMBL27584061 | 0.79 | HTR1D (0.46) | HTR1BHTR1D | |
| SCHEMBL27751359 | 0.77 | NR4A2 (0.52) | HTR1BHTR1DMTNR1AMTNR1B | |
| SCHEMBL28034299 | 0.77 | HTT (0.57) | HTR1BHTR1DHTTHTR1AMTNR1A | |
| SCHEMBL28034417 | 0.76 | HTT (0.56) | HTR1BHTR1DHTTHTR1AMTNR1A | |
| SCHEMBL27591862 | 0.75 | NR4A2 (0.52) | HTR1BHTR1DMTNR1AMTNR1BHTR2A | |
| SCHEMBL27752468 | 0.75 | HTR1D (0.45) | HTR1BHTR1DHTR1AMTNR1AMTNR1B | |
| SCHEMBL27667193 | 0.75 | HTR1D (0.50) | HTR1BHTR1DHTR1AKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1738814-A | Indolyl pyrazinone derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORP (US) | 2006-02-22 | — | — | CN | disclosed |