Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755481 | 0.82 | PTGDR2 (0.40) | ALPLDDR1EPHX2PTGDR2 | |
| SCHEMBL20303452 | 0.80 | EPAS1 (0.44) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL4477210 | 0.79 | MAPT (0.53) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL16373805 | 0.79 | FFAR4 (0.44) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL10562329 | 0.79 | FFAR4 (0.45) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL27624240 | 0.78 | VNN1 (0.46) | FFAR4TRPV1EPHX2TDP1 | |
| SCHEMBL24459310 | 0.76 | FFAR4 (0.41) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL21266901 | 0.76 | FFAR4 (0.41) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL4468349 | 0.76 | CCR5 (0.42) | FFAR4TRPV1MAPTCNR2ALPL | |
| SCHEMBL27624283 | 0.75 | FFAR4 (0.41) | FFAR4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100395234-C | Novel CB1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | CN | disclosed |
| CN-101012193-A | Novel CB 1 receptour inverse agonists | HOFFMANN LA ROCHE (CH) | 2007-08-08 | — | — | CN | disclosed |
| CN-1735593-A | Novel CB1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |