Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.60 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605518 | 0.80 | PARP1 (0.56) | NUDT1JAK3JAK1JAK2TYK2 | |
| SCHEMBL2878520 | 0.80 | NUDT1 (0.48) | NUDT1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12605516 | 0.80 | NUDT1 (0.47) | NUDT1JAK1JAK2TYK2CIT | |
| SCHEMBL31280881 | 0.79 | NUDT1 (0.56) | NUDT1JAK3JAK1JAK2TYK2 | |
| SCHEMBL23663615 | 0.79 | NUDT1 (0.56) | NUDT1JAK3JAK1JAK2TYK2 | |
| SCHEMBL7208445 | 0.77 | CYP4F2 (0.60) | CYP4F2CYP4A11CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13069320 | 0.77 | PRKCI (0.50) | NUDT1JAK3JAK1JAK2CIT | |
| SCHEMBL239630 | 0.76 | NUDT1 (0.54) | NUDT1JAK3JAK2CITPRKCI | |
| SCHEMBL14416608 | 0.76 | NUDT1 (0.52) | NUDT1JAK3JAK1JAK2TYK2 | |
| SCHEMBL14774643 | 0.76 | SMN1; SMN2 (0.59) | CYP4F2CYP4A11CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |