Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prochlorperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.74 |
| ▸ | LMNA | P02545 | 8/20 | 0.91 |
| ▸ | MAPT | P10636 | 7/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.91 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.91 |
| ▸ | MEN1 | O00255 | 4/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.91 |
| ▸ | GMNN | O75496 | 3/20 | 0.91 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.91 |
| ▸ | GAA | P10253 | 1/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.78 |
| ▸ | RAD52 | P43351 | 6/20 | 0.78 |
| ▸ | TP53 | P04637 | 5/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.78 |
| ▸ | USP2 | O75604 | 3/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | HRH1 | P35367 | 7/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochlorperazine SCHEMBL8914157 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL40755 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL29634451 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL718254 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL8911628 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL1806022 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL29686418 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL5494383 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL40756 | 0.95 | LMNA (1.00) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 | |
| Prochlorperazine SCHEMBL1527298 | 0.93 | MAPT (0.89) | LMNAMAPTMAPK1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1911465-B | Needle-free jet injection drug delivery device | ALZA CORP | 2011-05-11 | — | — | CN | disclosed |
| CN-1911465-A | Needle-free jet injection drug delivery device | ALZA CORP (US) | 2007-02-14 | — | — | CN | disclosed |