Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL5046830 | 0.91 | — | — | |
| Acrylic Acid SCHEMBL9061405 | 0.87 | LMNA (0.77) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL10801174 | 0.87 | LMNA (0.77) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL475312 | 0.87 | — | — | |
| Acrylic Acid SCHEMBL1950662 | 0.87 | LMNA (0.77) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL11242919 | 0.84 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL3361155 | 0.84 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL3273148 | 0.84 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL29230075 | 0.84 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN | |
| Acrylic Acid SCHEMBL11340305 | 0.84 | LMNA (0.71) | LMNAALDH1A1FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100504378-C | Method for preparing functional target disk of mass spectrum sample desorption by ground substance assistant laser | UNIV SHANGHAI JIAOTONG (CN) | 2009-06-24 | — | — | CN | disclosed |
| CN-101004408-A | Method for preparing functional target disk of mass spectrum sample de-absorbed by ground substance assistant laser | UNIV SHANGHAI JIAOTONG (CN) | 2007-07-25 | — | — | CN | disclosed |