Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | F7 | P08709 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | PYGL | P06737 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360314 | 0.87 | SMAD3 (0.62) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL2421110 | 0.86 | SMAD3 (0.57) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28474583 | 0.86 | PIN1 (0.59) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6512147 | 0.86 | SMAD3 (0.57) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28793315 | 0.86 | KDM4E (0.59) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL1144864 | 0.82 | PIN1 (0.63) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6990262 | 0.82 | SMAD3 (0.60) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL5970277 | 0.82 | KDM4E (0.63) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL15642858 | 0.82 | PLA2G4A (0.67) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL27590744 | 0.82 | SMAD3 (0.53) | SMAD3KDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972926-B | Indole derivatives as histamine receptor antagonists | HOFFMANN LA ROCHE | 2011-02-16 | — | — | CN | disclosed |
| CN-1972926-A | Indole derivatives as histamine receptor antagonists | HOFFMANN LA ROCHE (CH) | 2007-05-30 | — | — | CN | disclosed |