Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28765184 | 1.00 | DEPTOR (0.43) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL29711832 | 1.00 | DEPTOR (0.43) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL28765248 | 0.84 | DEPTOR (0.40) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL31482885 | 0.84 | DEPTOR (0.40) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL22968434 | 0.84 | DEPTOR (0.40) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL31482886 | 0.84 | DEPTOR (0.40) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL22968593 | 0.83 | NPC1 (0.50) | MAPTSMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL28765116 | 0.81 | TSHR (0.43) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL31482887 | 0.81 | TSHR (0.43) | DEPTORMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL31482884 | 0.81 | DEPTOR (0.40) | DEPTORMAPTSMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010325-A1 | IMPROVED SYNTHETIC METHODS OF MAKING (2H-1,2,3-TRIAZOL-2-YL)PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-06-15 | — | — | EP | disclosed |
| CN-114555603-A | Improved synthesis for the preparation of (2H-1,2, 3-triazol-2-yl) phenyl compounds as orexin receptor modulators | 詹森药业有限公司 | 2022-05-27 | — | — | CN | disclosed |