Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31482886 | 1.00 | DEPTOR (0.40) | DEPTORALDH1A1POLBGAANPSR1 | |
| SCHEMBL29711832 | 0.84 | DEPTOR (0.43) | DEPTORALDH1A1GAARAPGEF4SMN1; SMN2 | |
| SCHEMBL28765184 | 0.84 | DEPTOR (0.43) | DEPTORALDH1A1GAARAPGEF4SMN1; SMN2 | |
| SCHEMBL28765241 | 0.84 | DEPTOR (0.43) | DEPTORALDH1A1GAARAPGEF4SMN1; SMN2 | |
| SCHEMBL31482885 | 0.80 | DEPTOR (0.40) | DEPTORALDH1A1POLBGAARAPGEF4 | |
| SCHEMBL22968434 | 0.80 | DEPTOR (0.40) | DEPTORALDH1A1POLBGAARAPGEF4 | |
| SCHEMBL31482887 | 0.78 | TSHR (0.43) | DEPTORGAASMN1; SMN2MAPTTP53 | |
| SCHEMBL28765116 | 0.78 | TSHR (0.43) | DEPTORGAASMN1; SMN2MAPTTP53 | |
| SCHEMBL31482884 | 0.77 | DEPTOR (0.40) | DEPTORALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL28765252 | 0.77 | DEPTOR (0.40) | DEPTORALDH1A1GAASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570658-B2 | Synthetic methods of making (2H-1, 2, 3-triazol-2-yl) phenyl compounds as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-10 | — | — | US | disclosed |
| US-20220289754-A1 | IMPROVED SYNTHETIC METHODS OF MAKING (2H-1, 2, 3-TRIAZOL-2-YL) PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-15 | — | — | US | disclosed |
| EP-4010325-A1 | IMPROVED SYNTHETIC METHODS OF MAKING (2H-1,2,3-TRIAZOL-2-YL)PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-06-15 | — | — | EP | disclosed |
| CN-114555603-A | Improved synthesis for the preparation of (2H-1,2, 3-triazol-2-yl) phenyl compounds as orexin receptor modulators | 詹森药业有限公司 | 2022-05-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12570658-B2 | Synthetic methods of making (2H-1, 2, 3-triazol-2-yl) phenyl compounds as orexin receptor modulators | HCRTR2, HCRTR1, HRH1 | DEPTOR 806/4885ALDH1A1 895/4885POLB 3865/4885 |
| US-20220289754-A1 | IMPROVED SYNTHETIC METHODS OF MAKING (2H-1, 2, 3-TRIAZOL-2-YL) PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS | HCRTR2, HCRTR1, HTR3B | DEPTOR 416/4885ALDH1A1 2699/4885POLB 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.