SCHEMBL2876757

SCHEMBL2876757

Fc1ncccc1-c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.49
RIPK1 Q13546 1/20 0.47
LTA4H P09960 3/20 0.46
GRM5 P41594 1/20 0.46
DHODH Q02127 3/20 0.46
NISCH Q9Y2I1 1/20 0.45
FEN1 P39748 2/20 0.45
NPC1 O15118 1/20 0.44
SCN4A P35499 1/20 0.44
RAB9A P51151 1/20 0.44
CYP11B2 P19099 2/20 0.43
TLR8 Q9NR97 1/20 0.42
TSHR P16473 1/20 0.41
FFAR1 O14842 1/20 0.41
FFAR4 Q5NUL3 1/20 0.41
CYP11B1 P15538 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31051044 0.83 DHODH (0.50) GRM5DHODHNISCHNPC1CYP11B2
SCHEMBL3876408 0.83 DHODH (0.50) GRM5DHODHNISCHNPC1CYP11B2
SCHEMBL623507 0.79 MKNK1 (0.53) GSTP1RIPK1LTA4HFEN1NPC1
SCHEMBL3881160 0.77 CYP11B2 (0.50) DHODHCYP11B2CYP11B1
SCHEMBL31039974 0.76 BTK (0.51) GSTP1RIPK1LTA4HGRM5NISCH
SCHEMBL24196449 0.74 CYP11B2 (0.47) GRM5DHODHCYP11B2CYP11B1
SCHEMBL12947927 0.74 DHODH (0.48) DHODHCYP11B2CYP11B1
SCHEMBL22230844 0.74 CYP11B2 (0.47) RIPK1DHODHNPC1RAB9ACYP11B2
SCHEMBL18255779 0.74 CYP11B2 (0.47) RIPK1DHODHNPC1RAB9ACYP11B2
SCHEMBL3875252 0.74 CYP11B2 (0.55) DHODHCYP11B2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100216758-A1 Pyridone Compounds MSD K.K. (JP) 2010-08-26 US disclosed
EP-1916239-A1 PYRIDONE COMPOUND BANYU PHARMACEUTICAL CO., LTD. (JP) 2008-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216758-A1 Pyridone Compounds NPY1R, MC5R, MC1R GSTP1 4344/4885RIPK1 2201/4885LTA4H 529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.