Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.32 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768719 | 1.00 | OPRK1 (0.39) | OPRK1TACR1JAK3TEAD1POLB | |
| SCHEMBL3766440 | 0.84 | TACR1 (0.39) | TACR1POLBL3MBTL1 | |
| SCHEMBL20744897 | 0.84 | TACR1 (0.39) | TACR1POLBL3MBTL1 | |
| SCHEMBL3766415 | 0.84 | TACR1 (0.39) | TACR1POLBL3MBTL1 | |
| SCHEMBL28880008 | 0.79 | TACR1 (0.41) | OPRK1TACR1POLBL3MBTL1 | |
| SCHEMBL24543498 | 0.78 | NR1H2 (0.43) | OPRK1 | |
| SCHEMBL28766609 | 0.78 | NR1H2 (0.43) | OPRK1 | |
| SCHEMBL22969760 | 0.78 | OPRK1 (0.34) | OPRK1JAK3TEAD1TEAD3BTK | |
| SCHEMBL24543192 | 0.78 | OPRK1 (0.34) | OPRK1JAK3TEAD1TEAD3BTK | |
| SCHEMBL20571063 | 0.76 | TSHR (0.37) | JAK3L3MBTL1TET3KMT2AFBXL19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644631-A | KRAS G12C protein mutation inhibitor, preparation method thereof, pharmaceutical composition and application thereof | 上海维申医药有限公司 | 2022-06-21 | — | — | CN | disclosed |