Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456882 | 0.75 | CRBN (0.33) | DDB1CRBNBRD4TNFIL1B | |
| SCHEMBL30001714 | 0.74 | CRBN (0.44) | MEN1MAPK1KMT2ASMN1; SMN2DDB1 | |
| SCHEMBL476941 | 0.74 | CRBN (0.44) | MEN1MAPK1KMT2ASMN1; SMN2DDB1 | |
| SCHEMBL3739793 | 0.70 | DDB1 (0.43) | MEN1LMNAKMT2ASMN1; SMN2DDB1 | |
| SCHEMBL6542438 | 0.68 | DDB1 (0.32) | DDB1CRBN | |
| SCHEMBL27554480 | 0.63 | LMNA (0.33) | MEN1LMNAGLAPOLBMAPK1 | |
| SCHEMBL3756597 | 0.63 | CRBN (0.44) | MEN1KMT2ADDB1CRBNBRD4 | |
| SCHEMBL3996435 | 0.62 | CRBN (0.42) | MEN1LMNAGLAPOLBMAPK1 | |
| SCHEMBL3744126 | 0.62 | DDB1 (0.44) | DDB1CRBN | |
| SCHEMBL3744187 | 0.61 | CRBN (0.32) | MEN1KMT2ADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101557806-A | Methods and compositions for the treatment and control of spirochetes and other obligate intracellular bacterial diseases using immunomodulatory compounds | CELGENE CORP (US) | 2009-10-14 | — | — | CN | disclosed |
| CN-101124215-A | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders | CELGENE CORP (US) | 2008-02-13 | — | — | CN | disclosed |